Brain Whole-genome Landscape

Explore gene-phenotype associations utilizing the most comprehensive UK Biobank brain imaging phenotype data

Study population and data

Population

Brain imaging cohort

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Discovery cohort

(N=0)

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Replication
cohort 1

(N=0)

👥

Follow-up
cohort 2

(N=0)

WGS data

Genotype

Variants

0

Genes

0

Functional annotation category

CodingProximalRegulatory Five score metrics: GERPGnocchiJARVISSpliceAIREVEL

+

2,035 Brain imaging phenotypes

Structural MRI

Anatomical brain structure

Structural MRI

SWI

Venous blood & iron

SWI

Diffusion MRI

White matter tracts

Diffusion MRI

Functional MRI

Neural activity

Functional MRI

Whole-genome sequencing analysis

Variant-level analysis

0 loci discovered,

0 novel

Single variant testing plot

Gene-based analysis

0 gene-phenotype pairs discovered,

0 novel

Gene-based testing plot

Pleiotropy pattern

Pleiotropy pattern top row

Pleiotropy pattern bottom row

Clinical application

Heritability drives disase associations

Shared loci and genes with 46 brain disorders

Drug target identification for brain disorders

Mendelian randomization

Imaging

Confounders

SNP

Disorders

GERPML-GPSSafety scale

Biological annotation

MPRA

QTL mapping

Pathway enrichment

Cell type enrichment

For details about the data source and analysis methods used, please refer to the associated publication. If you use any findings from this site, please cite the paper.

Yang L. et al. Mapping the genomic landscape of human brain structure and function.